Cigarettes were stolen from an Ilkeston convenience store when raiders smashed through brickwork.
Burglars targeted the Famous Shop, in Bath Street, between 6pm on Saturday and 10am on Monday.
A police spokesman said the culprits tried to smash through the roof to get in but failed.
They then used an implement, possibly a sledgehammer, to smash through the brickwork before getting inside and taking tobacco and cigarettes.
Anyone with information should call 101.